PRP has been used medically for years to accelerate wound healing; repair tendon, ligament and joint damage; heal diabetic ulcers; and help regrow muscle and bone.
Platelets release protein growth factors vital to:
- Wound Healing + Scar Repair
- Tissue Regeneration
- Burn Healing
- Creating New Blood
PRP therapy has existed for decades, primarily used in orthopedic medicine to treat sports related injuries such as torn tendons.
In normal skin, the epidermis (outermost layer) and dermis (inner or deeper layer) act as a protective barrier against the external environment. Once the skin is broken, the normal process of healing is immediately set into motion. Immediately upon injury to the skin a set of complex events take place to repair the damage.
Within moments of an injury, platelets adhere to the site of injury, become activated, and aggregate (join together) creating a clot in the form of mesh of cross-linked fibrin protein. This clot stops active bleeding.
Scarring is body’s response to damaged tissue. Scars are the formation of fibrous tissue to replace damaged tissue, at the site of an injury. Virtually every wound will result in some degree of scarring. Sometimes the healing process is goes a bit too far creating red, raised scars known as hypertrophic scars. Sometimes, these scars can even extend far beyond the parameters of the original injury. These types of scars are referred to as Keloid scars.
Scar tissue is composed of the same protein collagen as the tissue that it replaces, but the fiber composition of the protein is different;instead of a random basket weave formation of the collagen fibers found in normal tissue, in fibrosis tissue the collagen cross-links and forms a pronounced alignment in a single direction. This collagen scar tissue alignment is usually of inferior functional quality to normal collagen. For example, scars in the skin are less resistant to ultraviolet radiation, and sweat glands and hair follicles do not grow back within scar tissues.
Platelet alpha granules are released into the wound promoting the migration and division of cells. New tissue and blood vessels are formed. During wound contraction, fibroblasts decrease the size of the wound by sticking to the wound’s edges and contracting, ultimately discarding unneeded cells. During maturation and remodeling collagen is remodeled and realigned.
However, the healing process is susceptible to interruption and even failure resulting in chronic wounds. Factors that contribute to non-healing chronic wounds are diabetes, venous or arterial disease, infection, and metabolic deficiencies of old age.